Development: How Tadpoles ROC Tail Regeneration
نویسندگان
چکیده
منابع مشابه
Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles.
Tail regeneration in Xenopus tadpoles is a favorable model system to understand the molecular and cellular basis of tissue regeneration. Although turnover of the extracellular matrix (ECM) is a key event during tissue injury and repair, no functional studies to evaluate its role in appendage regeneration have been performed. Studying the role of Hyaluronan (HA), an ECM component, is particularl...
متن کاملTemporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles
Bone morphogenetic protein (BMP) signalling is necessary for both the development of the tail bud and for tail regeneration in Xenopus laevis tadpoles. Using a stable transgenic line in which expression of the soluble BMP inhibitor noggin is under the control of the temperature inducible hsp70 promoter, we have investigated the timing of the requirement for BMP signalling during tail regenerati...
متن کاملArrested development in Xenopus laevis tadpoles: how size constrains metamorphosis.
Xenopus laevis tadpoles that arrest development and remain as larvae for several years sometimes occur spontaneously in laboratory populations. These tadpoles cease development at an early hindlimb stage, but continue to grow and develop into grossly deformed giants. Giant tadpoles lack thyroid glands, and differ in morphology and behaviour from normal larvae. They are negatively buoyant, typic...
متن کاملEffect of vitamin A on acid and alkaline phosphatase activities during tail regeneration in the tadpoles of the Asian toad
Anuran amphibians have the potential to restore their lost tail by regeneration, although, unlike urodeles their regeneration capacity is restricted to larval stages. Application of vitamin A or retinoids to tail amputated tadpoles causes abnormal tail regeneration and subsequently leads to development of ectopic organs (limbs and pelvic girdles) at the site of the tail, a phenomenon widely kno...
متن کاملTadpole tail regeneration in Xenopus.
Some organisms have a remarkable ability to heal wounds without scars and to regenerate complex tissues following injury. By gaining a more complete understanding of the biological mechanisms that promote scar-free healing and tissue regeneration, it is hoped that novel treatments that can enhance the healing and regenerative capacity of human patients can be found. In the present article, we b...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.06.026